Characteristics Of Patients With Lymphoma Diagnosis At Gunung Jati Cirebon Hospital In 2022-2024
DOI:
https://doi.org/10.47134/inhis.v5i1.140Keywords:
Limfoma, Limfoma Hodgkin, Limfoma Non-Hodgkin, KarakteristikAbstract
ABSTRACT
Background: Lymphoma is a malignancy of the lymphoid system that can involve lymph nodes and extranodal sites and remains a public health problem with an increasing incidence. Data on the characteristics of lymphoma patients in regional hospitals are still limited. Objective: To describe the characteristics of patients diagnosed with lymphoma at Gunung Jati Regional Hospital, Cirebon. Methods: This was a retrospective descriptive study using medical record data of lymphoma patients treated at Gunung Jati Regional Hospital during the period 2022–2024. Total sampling was applied. The variables analyzed included age, sex, clinical manifestations, tumor location, histopathological and immunohistochemical findings, treatment, and recurrence. Results: Of the 90 patients, most were male and belonged to the older age group. The most common clinical manifestation was a lump or mass, with predominant extranodal involvement. Most patients were diagnosed with Non-Hodgkin Lymphoma, with Diffuse Large B-Cell Lymphoma as the most frequent immunohistochemical subtype. Chemotherapy was the most commonly administered treatment, and no recurrence data were found during the observation period. Conclusion: Lymphoma patients at Gunung Jati Regional Hospital, Cirebon, during 2022–2024 were predominantly older males with extranodal involvement and Non-Hodgkin Lymphoma, particularly Diffuse Large B-Cell Lymphoma. These findings are important as a basis for clinical mapping and planning of lymphoma services in regional hospitals.
References
Adaniya, S. S., & Barta, S. K. (2021). 2021 Update on Diffuse large B cell lymphoma: A review of current data and potential applications on risk stratification and management. Am J Hematol.
Alwi, I. (2014). Textbook of Internal Medicine Volume II Edition VI. In Interna Publishing.
Ansell, S. M. (2024). Hodgkin lymphoma: 2025 update on diagnosis, risk-stratification, and management. In American Journal of Hematology. https://doi.org/10.1002/ajh.27470
Boddicker, N. J., Mwangi, R., Robinson, D. P., Allmer, C., Rosenthal, A. C., Habermann, T. M., Feldman, A. L., Rimsza, L. M., King, R. L., Larson, M. C., Negaard, B. J., Norman, A. D., Rajkumar, N., Ansell, S. M., Dispenzieri, A., Murray, D. L., Rajkumar, V., Kumar, S., Abeykoon, J. P., ... Cerhan, J. R. (2025). Risk of lymphoid malignancy associated with cancer predisposition genes. Blood Cancer Journal, 15(1). https://doi.org/10.1038/s41408-025-01283-z
Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R. L., Soerjomataram, I., & Jemal, A. (2024). Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Ca-A Cancer Journal for Clinicians, 11(1), 229–263.
Ferlay, J., Colombet, M., Soerjomataram, I., Parkin, D. M., Piñeros, M., Znaor, A., & Bray, F. (2024). Global Cancer Observatory: Cancer Today. International Agency for Research on Cancer. https://doi.org/10.1002/ijc.33588
Guerra, I., Bujanda, L., Manosa, M., Perez-Martinez, I., Casanova, M. J., & Pena, L. de la. (2023). Clinical Presentation, Management, and Evolution of Lymphomas in Patients with Inflammatory Bowel Disease: An ENEIDA. Cancers.
Harrison, T. ., Resnick, W. ., Wintrobe, M. ., Thorn, G. ., & Adams, R. . (2018). Harrison's Principals Of Internal Medicine (J. L. Jameson, D. L. Kasper, D. L. Longo, A. S. Fauci, S. L. Hauser, & J. Loscalzo (eds.); 20th Ed.). McGraw-Hill Education.
Huang, J., Pang, W. S., Lok, V., Zhang, L., Lucero-Prisno, D. E., Xu, W., Zheng, Z. J., Elcarte, E., Withers, M., & Wong, M. C. S. (2022). Incidence, mortality, risk factors, and trends for Hodgkin lymphoma: a global data analysis. Journal of Hematology and Oncology, 15(1), 1–11.
Karsten, I. E., Shumilov, E., Schmitz, N., & Lenz, G. (2024). Sequencing of therapy for patients with diffuse large B-cell lymphoma in the era of novel drugs. British Journal of Haematology.
Ministry of Health of the Republic of Indonesia. (2023). Decree of the Minister of Health Number HK.01.07/1337/2023 concerning Cancer Service Network Hospitals. 1–23.
Latifovic, L., Freeman, L. E. B., Spinelli, J. J., Pahwa, M., Kachuri, L., Blair, A., Cantor, K. P., Zahm, S. H., Weisenburger, D. D., McLaughlin, J. R., Dosman, J. A., Pahwa, P., Koutros, S., Demers, P. A., & Harris, S. A. (2020). Pesticide use and risk of Hodgkin lymphoma: results from the North American Pooled Project (NAPP). Cancer Causes and Control, 31(6), 583–599. https://doi.org/10.1007/s10552-020-01301-4
Lewis, W. D., Lilly, S., & Jones, K. L. (2020). Lymphoma : Diagnosis and treatment. 101(1).
Mamgain, G., Singh, P. K., Patra, P., Naithani, M., & Nath, U. K. (2022). Diffuse large B-cell lymphoma and new insights into its pathobiology and implication in treatment. Journal of Family Medicine and Primary Care, 169–170.
Momotow, J., Borchmann, S., Eichenauer, D. A., Engert, A., & Sasse, S. (2021). Hodgkin lymphoma—review on pathogenesis, diagnosis, current and future treatment approaches for adult patients. Journal of Clinical Medicine, 10(5), 1–17. https://doi.org/10.3390/jcm10051125
Morar, R., Varga, N., Raluca, C., Virzob, B., Balica, N. C., Horhat, I. D., Chioreanu, A., Sarau, O. S., Tanasescu, S., Susan, R., Mot, I. C., & Susan, R. (n.d.). Prognostic factors and relapse in nodal vs. extranodal non-Hodgkin lymphoma of the ENT region : a prospective cohort study. April 2025, 1–7. https://doi.org/10.25122/jml-2025-0064
Nolan, J., Saputra, H., Susraini, A. A. A. N., & Sumadi, I. W. J. (2021). Profile of Non-Hodgkin Malignant Lymphoma according to WHO classification and working formulation in the anatomical pathology laboratory of Sanglah Hospital Denpasar for the period of 2016 – 2018. E-Journal of Udayana MedicineJournal of Udayana Medicine, 10(9), 4–9.
Octavia, T. A., Irfandy, D., Budiman, B. J., & Majorita, P. (2023). Diagnosis and management of non-Hodgkin lymphoma type B cell synonysal Andalas Medical Magazine, 46(6), 1103–1117. https://doi.org/10.25077/mka.v46.i6.p1103-1117.2023
Oehadian, A., Kartikasari, A., Mersiana, L., Gunadi, S. V., Fungani, G., Vidyaniati, P., Prasetya, D., Wijaya, I., Fianza, P. I., Fadjari, T. H., & Sutedjo, N. N. (2024). Clinical and histopathological overview of Non-Hodgkin Lymphoma of the digestive system at Dr. Hasan Sadikin Hospital Bandung in 2018-2020. Journal of Blood Medicine, 15, 341–349. https://doi.org/10.2147/JBM.S472791
Rojek, A. E., & Smith, S. M. (2022). Evolution of therapy for limited stage diffuse large B-cell lymphoma. Blood Cancer Journal.
Serin, I., Ulusoy, A., Onar, M. I., & Dogu, M. H. (2020). Recurrence of lymphoma with isolated pericardial mass: A case report. Journal of Medical Case Reports, 14(1), 1–5. https://doi.org/10.1186/s13256-020-02508-4
Sezgin, M. G., & Bektas, H. (2022). A Retrospective Examination of Symptoms Experienced by Patients Diagnosed with Lymphoma, Reasons for Hospital Admission, Hospitalization, and Hospital Treatments. Journal of Education and Research in Nursing, 19(4), 437–444. https://doi.org/10.5152/jern.2022.50480
Storck, K., Brandstetter, M., Keller, U., & Knopf, A. (2019). Clinical presentation and characteristics of lymphoma in the head and neck region. Head and Face Medicine, 15(1), 4–11. https://doi.org/10.1186/s13005-018-0186-0
Tasyandita, R. M., Yulianti, H., & Hernowo, B. S. (2023). Clinical and histopathological features of Non-Hodgkin Lymphoma in gastrointestinal system at RSUP Dr. Hasan Sadikin Bandung 2018-2020. Indonesian Pathology Magazine, 32(1), 542–547. https://doi.org/10.55816/mpi.v32i1.562
Thandra, K. C., Barsouk, A., Saginala, K., Padala, S. A., Barsouk, A., & Rawla, P. (2021). Epidemiology of non-Hodgkin's lymphomas. Medical Science, 9(5). https://doi.org/10.1159/000411699
Wang, J., Conti, D. V., Epeldegui, M., Ollikainen, M., Tyndale, R. F., Hwang, A. E., Magpantay, L., Mack, T. M., Martinez-maza, O., Kaprio, J., & Cozen, W. (2021). Lymphoma-associated biomarkers are increased in current smokers in twin pairs discordant for smoking. Cancers, 13(21), 2–13. https://doi.org/10.3390/cancers13215395
Wang, L., Qin, W., Huo, Y. J., Li, X., Shi, Q., Rasko, J. E. J., Janin, A., & Zhao, W. L. (2020). Advances in targeted therapy for malignant lymphoma. Signal Transduction and Targeted Therapy, 5(1). https://doi.org/10.1038/s41392-020-0113-2
Wibawa, I. K. P. A., & Ekawati, N. P. (2021). Characteristics of Malignant Lymphoma patients at Sanglah Central General Hospital Denpasar Bali in 2018. E-Journal of Udayana Medicine, 10(10), 99. https://doi.org/10.24843/mu.2021.v10.i10.p16
Yan, S., Ma, J., Yang, M., Liu, B., Li, S., Yang, L., Zhang, Q., & Li, X. (2022). Analysis of the Clinicopathologic Characteristics and Prognosis of Head and Neck Lymphoma. Analytical Cellular Pathology, 2022. https://doi.org/10.1155/2022/4936099
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Indonesian Health Issue
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
